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Structure of 2230200-76-5
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(S)-Methyl 2-(chloromethyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate features a chiral oxetane-bearing side chain that enhances membrane permeability and metabolic stability. The chloromethyl group enables site-specific functionalization, while the benzoimidazole core provides a rigid, electron-deficient scaffold ideal for medicinal chemistry applications. This compound serves as a key building block in the synthesis of targeted covalent inhibitors.
(S)-Methyl 2-(chloromethyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate serves as a versatile synthetic intermediate for constructing bioactive heterocycles. The chloromethyl group enables efficient nucleophilic substitution, while the oxetane ring imparts metabolic stability and favorable physicochemical properties. This scaffold facilitates rapid diversification in medicinal chemistry campaigns, particularly in kinase inhibitor and CNS-targeted compound development. Its bench-stable nature and compatibility with standard coupling protocols support scalable synthesis and purification.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314
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Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501
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Lot numbers can be found on the outside label of a product: