N-Me-Thalidomide 4-fluoride

Name: N-Me-Thalidomide 4-fluoride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2244520-92-9
Cat. No. CS-0527789
Purity≥98%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 2244520-92-9

Size

Price

Quantity

* Please select Quantity before adding items.

Description

N-Me-Thalidomide 4-fluoride features a methylated amide nitrogen and a para-fluorine substituent, enhancing metabolic stability and modulating electronic properties. This derivative exhibits improved lipophilicity and bench-stability compared to parent thalidomide, facilitating direct incorporation into medicinal chemistry campaigns targeting immunomodulatory pathways.

Application

N-Me-Thalidomide 4-fluoride serves as a synthetically accessible analog for probing the structure-activity relationships of immunomodulatory imide drugs. Its fluorinated aryl moiety enhances metabolic stability and modulates electronic properties, while the N-methyl substitution improves solubility and pharmacokinetic profile. The compound functions as a versatile building block in medicinal chemistry campaigns targeting cereblon-binding scaffolds, enabling efficient synthesis of derivatives via standard coupling and functionalization protocols.

General Information

CAS No. 2244520-92-9
Cat. No. CS-0527789
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₁₁FN₂O₄
Molecular Weight 290.25
Synonym(s) None
SMILES O=C1C2=C(C(N1C3C(N(C)C(CC3)=O)=O)=O)C(F)=CC=C2

Computational Chemistry Data

TPSA 74.76
LogP 0.4631
H_Acceptors 6
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

N-Me-Thalidomide 4-fluoride sigmaN-Me-Thalidomide 4-fluoride manufacturerN-Me-Thalidomide 4-fluoride priceN-Me-Thalidomide 4-fluoride structureN-Me-Thalidomide 4-fluoride SDSbuy N-Me-Thalidomide 4-fluorideN-Me-Thalidomide 4-fluoride supplierN-Me-Thalidomide 4-fluoride usesN-Me-Thalidomide 4-fluoride molecular weightprice of N-Me-Thalidomide 4-fluorideN-Me-Thalidomide 4-fluoride chemical name formula of N-Me-Thalidomide 4-fluoride

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

N-Me-Thalidomide 4-fluoride

CAS No. 2244520-92-9

Recommended Products