(R)-4-Isopropyl-2-(1,8-naphthyridin-2-yl)-4,5-dihydrooxazole

Name: (R)-4-Isopropyl-2-(1,8-naphthyridin-2-yl)-4,5-dihydrooxazole
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2757082-67-8
Cat. No. CS-0179434
Molecule weight241.29
Purity≥95%
MDL No.None

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(R)-4-Isopropyl-2-(1,8-naphthyridin-2-yl)-4,5-dihydrooxazole|CS-0179434

Structure of 2757082-67-8

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General Information

CAS No. 2757082-67-8
Cat. No. CS-0179434
Purity ≥95%
MDL No. None
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₁₅N₃O
Molecular Weight 241.29
Synonym(s) None
SMILES CC([C@@H]1COC(C2=NC3=NC=CC=C3C=C2)=N1)C

Description

(R)-4-Isopropyl-2-(1,8-naphthyridin-2-yl)-4,5-dihydrooxazole is a stereodefined heterocyclic scaffold featuring a chiral center at the 4-position and a fused 1,8-naphthyridine moiety. This configuration imparts enhanced binding affinity and metabolic stability in targeted kinase inhibition studies. The molecule exhibits favorable solubility and bench-stability under standard conditions, enabling straightforward integration into medicinal chemistry campaigns.

Application

(R)-4-Isopropyl-2-(1,8-naphthyridin-2-yl)-4,5-dihydrooxazole serves as a versatile chiral building block in medicinal chemistry, enabling the construction of complex heterocyclic scaffolds. Its dihydrooxazole core exhibits excellent bench stability and functional group tolerance, facilitating downstream transformations such as hydrogenation or nucleophilic addition. The molecule functions effectively in transition-metal-catalyzed coupling reactions and provides a rigid, stereochemically defined framework for targeted ligand design.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 47.37
LogP 2.4312
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Key Words

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(R)-4-Isopropyl-2-(1,8-naphthyridin-2-yl)-4,5-dihydrooxazole

CAS No. 2757082-67-8

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