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CS-W001157 4
Total: USD 88.00

4-trans-Hydroxycyclohexylamine

  • CAS No. 27489-62-9

  • Cat. No. CS-W019841
  • Purity≥97%
  • MDL No.MFCD00067698

*For research and further manufacturing use only, not for direct human use.

4-trans-Hydroxycyclohexylamine|CS-W019841

Structure of 27489-62-9

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General Information

  • CAS No. 27489-62-9
  • Cat. No. CS-W019841
  • Purity ≥97%
  • MDL No. MFCD00067698
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃NO
  • Molecular Weight 115.17
  • Synonym(s) trans-4-Aminocyclohexan-1-ol
  • SMILES N[C@H]1CC[C@H](O)CC1

Description

4-trans-Hydroxycyclohexylamine offers a stable, bench-ready platform for cyclohexane-based bioconjugation and medicinal chemistry. The trans-configured hydroxyl and amine groups enable precise spatial orientation, facilitating efficient coupling reactions while maintaining solubility in common organic solvents.

Application

4-Trans-Hydroxycyclohexylamine serves as a versatile chiral building block in medicinal chemistry, enabling access to bioactive scaffolds through established functional group transformations. Its trans-configured cyclohexane ring provides conformational rigidity beneficial for structure-activity studies, while the primary amine and hydroxyl groups offer orthogonal reactivity for derivatization. The compound exhibits good bench stability and is compatible with standard coupling, protection, and oxidation protocols, facilitating efficient synthesis of targeted molecules.

Synthesis

  • Route1
    • null|null
      1380214-98-1
    • ~95%
    • In-stock
      4-trans-Hydroxycyclohexylamine|CS-W019841
      27489-62-9

    References

    • Advanced Synthesis and Catalysis, , vol. 354, # 8 p. 1417 - 1421
  • Route2

    References

    • WO2007/62334 A2, ; Page/Page column 11 ;
  • Route3
    • null|null
      123-30-8
    • ~%
    • In-stock
      4-trans-Hydroxycyclohexylamine|CS-W019841
      27489-62-9
    • In-stock
      4-Aminocyclohexan-1-ol|CS-W019318
      6850-65-3

    References

    • Journal of the American Chemical Society, , vol. 80, p. 6412,6419

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   0.2486
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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