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CS-W001157 4
Total: USD 88.00

imidazo[1,2-a]pyrimidine

  • CAS No. 274-95-3

  • Cat. No. CS-W003279
  • Purity≥96%
  • MDL No.MFCD06245377

*For research and further manufacturing use only, not for direct human use.

imidazo[1,2-a]pyrimidine|CS-W003279

Structure of 274-95-3

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General Information

  • CAS No. 274-95-3
  • Cat. No. CS-W003279
  • Purity ≥96%
  • MDL No. MFCD06245377
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅N₃
  • Molecular Weight 119.12
  • Synonym(s) Imidazo[1,2-a]pyrimidin
  • SMILES c1ccn2c(n1)ncc2

Description

Imidazo[1,2-a]pyrimidine serves as a privileged heterocyclic scaffold in medicinal chemistry, offering enhanced bioavailability and metabolic stability. This nitrogen-rich core integrates readily into kinase inhibitors and antiviral agents, where its planar structure supports π-stacking interactions. The system demonstrates robust performance under standard bench conditions, enabling efficient incorporation into diverse molecular architectures.

Synthesis

  • Route1
    • In-stock
      2-Aminopyrimidine|CS-W020110
      109-12-6
    • null|null
      107-20-0
    • ~75%
    • In-stock
      imidazo[1,2-a]pyrimidine|CS-W003279
      274-95-3

    References

    • Loeber, Stefan; Huebner, Harald; Gmeiner, Peter Bioorganic & Medicinal Chemistry Letters, 1999 , vol. 9, # 1 p. 97 - 102
  • Route2

    References

    • Kuenstlinger, M.; Breitmaier, E. Synthesis, 1983 , # 2 p. 161 - 162
  • Route3
    • null|null
      764-63-6
    • In-stock
      1H-imidazol-2-amine sulfate(2:1)|CS-W002088
      1450-93-7
    • ~67%
    • In-stock
      imidazo[1,2-a]pyrimidine|CS-W003279
      274-95-3

    References

    • Kuenstlinger, M.; Breitmaier, E. Synthesis, 1983 , # 2 p. 161 - 162

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   0.7293
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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