Lot numbers can be found on the outside label of a product:
1-Methyl-1H-pyrrolo[2,3-b]pyridine
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CAS No. 27257-15-4
- Cat. No. CS-W001520
- Purity≥98%
- MDL No.MFCD09743451
*For research and further manufacturing use only, not for direct human use.
![1-Methyl-1H-pyrrolo[2,3-b]pyridine|CS-W001520](https://file.chemscene.com/productPIC/CS-W001520.gif)
Structure of 27257-15-4
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General Information
- CAS No. 27257-15-4
- Cat. No. CS-W001520
- Purity ≥98%
- MDL No. MFCD09743451
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₈N₂
- Molecular Weight 132.16
- Synonym(s) None
- SMILES CN1C=CC2=C1N=CC=C2
Description
1-Methyl-1H-pyrrolo[2,3-b]pyridine is a heterocyclic scaffold featuring a fused pyrrole-pyridine core with a methyl group at the nitrogen atom. This electron-rich system serves as a key building block in medicinal chemistry, offering enhanced solubility and metabolic stability. Its rigid, planar structure facilitates π-stacking interactions in target binding. The compound integrates readily into diverse synthetic routes for bioactive molecules.
Application
1-Methyl-1H-pyrrolo[2,3-b]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to structurally diverse scaffolds. Its inherent stability and favorable solubility facilitate straightforward functionalization at multiple positions. The molecule functions effectively in cross-coupling reactions and serves as a core framework for constructing bioactive compounds, particularly in kinase inhibitor and CNS-targeted drug discovery programs.
Synthesis
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Route1
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In-stock
271-63-6 -
74-88-4 - ~99%
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In-stock
27257-15-4
References
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Kannaboina, Prakash; Anilkumar; Aravinda; Vishwakarma, Ram A.; Das, Parthasarathi Organic Letters, 2013 , vol. 15, # 22 p. 5718 - 5721
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Route2
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74-88-4
- ~99%
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In-stock
27257-15-4
References
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ELI LILLY AND COMPANY Patent: WO2006/107784 A1, 2006 ; Location in patent: Page/Page column 63-63 ; WO 2006/107784 A1
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Route3
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In-stock
271-63-6
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62018-65-9
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74-88-4
- ~87%
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In-stock
27257-15-4
References
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DAIICHI PHARMACEUTICAL CO., LTD. Patent: EP1346982 A1, 2003 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 17.82
- LogP 1.5733
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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