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CS-W001157 4
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(S)-2-Amino-3-(1h-pyrazol-1-yl)propanoic acid

  • CAS No. 2734-48-7

  • Cat. No. CS-0199833
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-2-Amino-3-(1h-pyrazol-1-yl)propanoic acid|CS-0199833

Structure of 2734-48-7

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General Information

  • CAS No. 2734-48-7
  • Cat. No. CS-0199833
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃O₂
  • Molecular Weight 155.15
  • Synonym(s) 3-(Pyrazol-1-yl)-L-alanine
  • SMILES C1=CN(C[C@@H](C(=O)O)N)N=C1

Description

(S)-2-Amino-3-(1H-pyrazol-1-yl)propanoic acid is a chiral amino acid derivative featuring a pyrazole ring at the β-position, enabling integration into bioactive peptide architectures. The scaffold provides enhanced metabolic stability and hydrogen-bonding capacity, supporting its use in medicinal chemistry campaigns targeting CNS receptors and enzyme inhibitors.

Synthesis

  • Route1
    • (S)-2-(((benzyloxy)carbonyl)amino)-3-(1H-pyrazol-1-yl)propanoic acid|CS-0449620
      20945-53-3
    • ~%
    • In-stock
      (S)-2-Amino-3-(1h-pyrazol-1-yl)propanoic acid|CS-0199833
      2734-48-7

    References

    • Bristol-Myers Squibb Company Patent: US2008/44379 A1, 2008 ; Location in patent: Page/Page column 63 ;
  • Route2
    • In-stock
      1H-pyrazole|CS-W008829
      288-13-1
    • (S)-3-Amino-2-oxetanone p-toluenesulfonic acid salt|CS-0054576
      112839-95-9
    • ~77%
    • In-stock
      (S)-2-Amino-3-(1h-pyrazol-1-yl)propanoic acid|CS-0199833
      2734-48-7

    References

    • Arnold,L.D.; May,R.G.; Vederas,J.C. Journal of the American Chemical Society, 1988 , vol. 110, p. 2237
  • Route3

    References

    • Murakoshi, Isamu; Ikegami, Fumio; Yoneda, Yoshihiro; Ihara, Harumi; Sakata, Kumiko; Koide, Chiharu Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1473 - 1478

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   81.14
  • LogP   -0.705
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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