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L-Glutamyl-glycine

  • CAS No. 13716-89-7

  • Cat. No. CS-0210611
  • Purity≥97%
  • MDL No.MFCD00037311

*For research and further manufacturing use only, not for direct human use.

L-Glutamyl-glycine|CS-0210611

Structure of 13716-89-7

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General Information

  • CAS No. 13716-89-7
  • Cat. No. CS-0210611
  • Purity ≥97%
  • MDL No. MFCD00037311
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₂N₂O₅
  • Molecular Weight 204.18
  • Synonym(s) Glu-Gly
  • SMILES O=C(O)CC[C@H](N)C(NCC(O)=O)=O

Description

L-Glutamyl-glycine is a dipeptide featuring a glutamic acid residue linked via its γ-carboxyl group to the amino terminus of glycine. This structure imparts enhanced solubility and metabolic stability, enabling direct incorporation into peptide synthesis workflows without requiring protection of the side-chain carboxylate.

Application

L-Glutamyl-glycine serves as a stable dipeptide building block for peptide synthesis, offering reliable coupling efficiency and orthogonal protection compatibility. Its glutamyl moiety provides a versatile handle for further functionalization, while the glycine residue ensures minimal steric hindrance during chain elongation. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • Amiard et al. Bulletin de la Societe Chimique de France, 1956 , p. 97,100
  • Route2
    • Benzyl n-[(3S)-2,6-dioxooxan-3-yl]carbamate|CS-0256477
      4124-76-9
    • ~%
    • In-stock
      L-Glutamyl-glycine|CS-0210611
      13716-89-7

    References

    • Grassmann; Schneider Biochemische Zeitschrift, 1934 , vol. 273, p. 455,460
  • Route3
    • null|null
      25126-07-2
    • ~%
    • In-stock
      L-Glutamyl-glycine|CS-0210611
      13716-89-7

    References

    • Klieger,E.; Schroeder,E. Justus Liebigs Annalen der Chemie, 1963 , vol. 661, p. 193 - 201

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   129.72
  • LogP   -1.6207
  • H_Acceptors   4
  • H_Donors   4
  • Rotatable_Bonds   6

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