Thiazolo[5,4-c]pyridine

Name: Thiazolo[5,4-c]pyridine
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CAS No. 273-70-1
Cat. No. CS-0145519
Purity≥97%
MDL No.None

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Type	HazMat Fee
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FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 273-70-1
Cat. No. CS-0145519
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄N₂S
Molecular Weight 136.17
Synonym(s) thiazolo[5,4-c]-pyridine
SMILES C1(SC=N2)=C2C=CN=C1

Description

Thiazolo[5,4-c]pyridine delivers a rigid, electron-deficient heteroaromatic scaffold ideal for constructing bioactive molecules and functional materials. This fused bicyclic system combines enhanced stability with tunable electronic properties, enabling efficient integration into pharmaceutical candidates and organic semiconductors under standard conditions.

Application

Thiazolo[5,4-c]pyridine serves as a privileged heterocyclic scaffold in medicinal chemistry, offering enhanced metabolic stability and π-stacking capability due to its planar, electron-deficient structure. It functions as a versatile building block in the synthesis of kinase inhibitors and other bioactive molecules, enabling efficient functionalization at multiple positions via palladium-catalyzed cross-coupling. The core exhibits excellent bench stability and compatibility with common protecting groups, facilitating modular assembly in multi-step syntheses.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 1.6913
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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Thiazolo[5,4-c]pyridine

CAS No. 273-70-1

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