Lot numbers can be found on the outside label of a product:
1-Tosylpiperazine
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CAS No. 27106-51-0
- Cat. No. CS-0167940
- Purity≥97%
- MDL No.MFCD02018961
*For research and further manufacturing use only, not for direct human use.
Structure of 27106-51-0
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General Information
- CAS No. 27106-51-0
- Cat. No. CS-0167940
- Purity ≥97%
- MDL No. MFCD02018961
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₆N₂O₂S
- Molecular Weight 240.32
- Synonym(s) 1-(Toluene-4-sulfonyl)piperazine
- SMILES O=S(N1CCNCC1)(C2=CC=C(C)C=C2)=O
Description
1-Tosylpiperazine features a piperazine core functionalized with a tosyl group, delivering a robust scaffold for medicinal chemistry. This electron-deficient aromatic moiety enhances solubility and metabolic stability in drug discovery applications. The tosyl handle enables efficient derivatization under standard coupling conditions.
Application
1-Tosylpiperazine serves as a versatile building block in medicinal chemistry, enabling the construction of complex heterocyclic scaffolds through standard coupling and functionalization reactions. Its tosyl group provides excellent stability and facilitates selective derivatization, while the piperazine core offers favorable solubility and metabolic resilience. The compound functions reliably in multistep syntheses and is well-suited for scale-up due to its bench-stable nature and straightforward purification.
Synthesis
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Route1
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110-85-0 -
98-59-9
- ~99%
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In-stock
27106-51-0
References
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Sanraku-Ocean Co., Ltd. Patent: US3943135 A1, 1976 ;
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Route2
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142-64-3
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In-stock
2232-08-8 - ~86%
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In-stock
27106-51-0
References
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Verma, Sanjeev K.; Acharya; Kaushik Organic Letters, 2010 , vol. 12, # 19 p. 4232 - 4235
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Route3
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110-85-0
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In-stock
2232-08-8
- ~%
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In-stock
27106-51-0
References
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Verma, Sanjeev K.; Acharya; Kaushik Organic Letters, 2010 , vol. 12, # 19 p. 4232 - 4235
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 49.41
- LogP 0.58892
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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