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CS-W001157 4
Total: USD 88.00

1-(Methylsulfonyl)piperazine

  • CAS No. 55276-43-2

  • Cat. No. CS-W002889
  • Purity≥97%
  • MDL No.MFCD02153225

*For research and further manufacturing use only, not for direct human use.

1-(Methylsulfonyl)piperazine|CS-W002889

Structure of 55276-43-2

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General Information

  • CAS No. 55276-43-2
  • Cat. No. CS-W002889
  • Purity ≥97%
  • MDL No. MFCD02153225
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂N₂O₂S
  • Molecular Weight 164.23
  • Synonym(s) Piperazine, 1-(methylsulfonyl)-
  • SMILES CS(=O)(=O)N1CCNCC1

Description

1-(Methylsulfonyl)piperazine is a bench-stable, electron-deficient heterocycle featuring a polar methylsulfonyl group that enhances solubility and metabolic stability. This functionalized piperazine integrates readily into medicinal chemistry scaffolds, serving as a key building block for bioactive molecules in drug discovery programs.

Application

1-(Methylsulfonyl)piperazine serves as a versatile, bench-stable building block in medicinal chemistry, enabling the introduction of a polar, metabolically robust sulfonamide moiety. Its amine functionality facilitates straightforward derivatization via nucleophilic substitution or reductive amination, while the methylsulfonyl group enhances solubility and modulates pharmacokinetic properties. This compound functions effectively in the construction of heterocyclic scaffolds and bioactive molecules requiring controlled polarity and hydrogen-bonding capacity.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.41
  • LogP   -1.1488
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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