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CS-W001157 4
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4,4'-(Chloromethylene)bis(fluorobenzene)

  • CAS No. 27064-94-4

  • Cat. No. CS-W010304
  • Purity≥97%
  • MDL No.MFCD00044329

*For research and further manufacturing use only, not for direct human use.

4,4'-(Chloromethylene)bis(fluorobenzene)|CS-W010304

Structure of 27064-94-4

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General Information

  • CAS No. 27064-94-4
  • Cat. No. CS-W010304
  • Purity ≥97%
  • MDL No. MFCD00044329
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₉ClF₂
  • Molecular Weight 238.66
  • Synonym(s) α-Chloro-4,4'-difluorodiphenylmethane
  • SMILES FC1=CC=C(C=C1)C(Cl)C1=CC=C(F)C=C1

Application

4,4'-(Chloromethylene)bis(fluorobenzene) serves as a versatile bifunctional building block in synthetic organic chemistry, enabling the construction of symmetric biaryl scaffolds through palladium-catalyzed cross-coupling reactions. The chloromethylene bridge provides a robust linkage for further functionalization, while the fluorinated aryl groups offer enhanced stability and orthogonal reactivity. Its bench-stable nature and compatibility with standard coupling protocols make it ideal for the modular synthesis of complex molecular architectures in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Valenta, Vladimir; Urban, Jiri; Taimr, Jan; Polivka, Zdenek Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 5 p. 1126 - 1136
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      4,4'-(Chloromethylene)bis(fluorobenzene)|CS-W010304
      27064-94-4

    References

    • Sankyo Company Limited Patent: US5028610 A1, 1991 ;
  • Route3

    References

    • Shivprakash; Reddy, G. Chandrasekara Synthetic Communications, 2014 , vol. 44, # 5 p. 600 - 609

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314-H335
Precautionary Statements : P261-P264-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   4.293
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   2

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