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CS-W001157 4
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Ethyl pipecolinate

  • CAS No. 15862-72-3

  • Cat. No. CS-0043929
  • Purity≥97%
  • MDL No.MFCD00005980

*For research and further manufacturing use only, not for direct human use.

Ethyl pipecolinate|CS-0043929

Structure of 15862-72-3

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General Information

  • CAS No. 15862-72-3
  • Cat. No. CS-0043929
  • Purity ≥97%
  • MDL No. MFCD00005980
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅NO₂
  • Molecular Weight 157.21
  • Synonym(s) Pipecolinic Acid Ethyl Ester
  • SMILES O=C(OCC)C1CCCCN1

Description

Ethyl pipecolinate features a cyclic tertiary amine structure that enhances solubility and stability in organic media. This versatile ester integrates readily into synthetic sequences, serving as a key intermediate for pharmaceuticals and agrochemicals. The ethyl ester group enables efficient derivatization under standard conditions.

Application

Ethyl pipecolinate serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to piperidine-containing scaffolds prevalent in bioactive molecules. Its ester functionality facilitates straightforward derivatization, while the cyclic amine exhibits favorable stability and compatibility with standard synthetic transformations, including reductive amination and cross-coupling reactions.

Synthesis

  • Route1

    References

    • Studer, Martin; Wedemeyer-Exl, Christina; Spindler, Felix; Blaser, Hans-Ulrich Monatshefte fur Chemie, 2000 , vol. 131, # 12 p. 1335 - 1343
  • Route2
    • null|null
      64-17-5
    • null|null
      4043-87-2
    • ~93%
    • In-stock
      Ethyl pipecolinate|CS-0043929
      15862-72-3

    References

    • Su, Hongying; Wu, Changqiang; Zhu, Jiang; Miao, Tianxin; Wang, Dan; Xia, Chunchao; Zhao, Xuna; Gong, Qiyong; Song, Bin; Ai, Hua Dalton Transactions, 2012 , vol. 41, # 48 p. 14480 - 14483
  • Route3
    • null|null
      4043-87-2
    • ~%
    • In-stock
      Ethyl pipecolinate|CS-0043929
      15862-72-3

    References

    • Journal of the Chemical Society, , p. 437,441

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   0.6916
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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