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7-Methylnaphthalen-2-ol

  • CAS No. 26593-50-0

  • Cat. No. CS-0197097
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Methylnaphthalen-2-ol|CS-0197097

Structure of 26593-50-0

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General Information

  • CAS No. 26593-50-0
  • Cat. No. CS-0197097
  • Purity ≥96%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀O
  • Molecular Weight 158.20
  • Synonym(s) 7-METHYL-2-NAPHTHOL
  • SMILES OC1=CC=C2C=CC(C)=CC2=C1

Description

7-Methylnaphthalen-2-ol features a naphthalene core with a hydroxyl group at position 2 and a methyl substituent at position 7, delivering enhanced solubility and stability compared to unsubstituted analogs. This configuration enables efficient integration into synthetic pathways requiring electron-rich aromatic scaffolds.

Application

7-Methylnaphthalen-2-ol serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the phenolic OH group and facilitating electrophilic substitution at electron-rich positions. Its stability under standard bench conditions and compatibility with common coupling reactions make it valuable for constructing complex polycyclic frameworks. The molecule functions effectively in the synthesis of advanced intermediates for pharmaceuticals and agrochemicals, particularly where naphthalene-based scaffolds are required.

Synthesis

  • Route1

    References

    • Ewing, William R.; Becker, Michael R.; Manetta, Vincent E.; Davis, Roderick S.; Pauls, Henry W.; Mason, Helen; Choi-Sledeski, Yong Mi; Green, Daniel; Cha, Don; Spada, Alfred P.; Cheney, Daniel L.; Mason, Jonathan S.; Maignan, Sebastien; Guilloteau, Jean-Pierre; Brown, Karen; Colussi, Dennis; Bentley, Ross; Bostwick, Jeff; Kasiewski, Charles J.; Morgan, Suzanne R.; Leadley, Robert J.; Dunwiddie, Christopher T.; Perrone, Mark H.; Chu, Valeria Journal of Medicinal Chemistry, 1999 , vol. 42, # 18 p. 3557 - 3571
  • Route2
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    • In-stock
      7-Methylnaphthalen-2-ol|CS-0197097
      26593-50-0

    References

    • Ewing, William R.; Becker, Michael R.; Manetta, Vincent E.; Davis, Roderick S.; Pauls, Henry W.; Mason, Helen; Choi-Sledeski, Yong Mi; Green, Daniel; Cha, Don; Spada, Alfred P.; Cheney, Daniel L.; Mason, Jonathan S.; Maignan, Sebastien; Guilloteau, Jean-Pierre; Brown, Karen; Colussi, Dennis; Bentley, Ross; Bostwick, Jeff; Kasiewski, Charles J.; Morgan, Suzanne R.; Leadley, Robert J.; Dunwiddie, Christopher T.; Perrone, Mark H.; Chu, Valeria Journal of Medicinal Chemistry, 1999 , vol. 42, # 18 p. 3557 - 3571
  • Route3
    • 7-Methoxy-1-tetralone Agomelatine Impurity|CS-0214044
      6836-19-7
    • ~%
    • In-stock
      7-Methylnaphthalen-2-ol|CS-0197097
      26593-50-0

    References

    • Strasser; Cooper; Dewald; Payne Helvetica Chimica Acta, 1988 , vol. 71, # 5 p. 1156 - 1176

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335-H412
Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.85382
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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