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3-Methylnaphthalen-2-ol

  • CAS No. 17324-04-8

  • Cat. No. CS-0145779
  • Purity≥95%
  • MDL No.MFCD09037754

*For research and further manufacturing use only, not for direct human use.

3-Methylnaphthalen-2-ol|CS-0145779

Structure of 17324-04-8

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General Information

  • CAS No. 17324-04-8
  • Cat. No. CS-0145779
  • Purity ≥95%
  • MDL No. MFCD09037754
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀O
  • Molecular Weight 158.20
  • Synonym(s) Einecs 241-346-4
  • SMILES OC1=C(C=C2C=CC=CC2=C1)C

Description

3-Methylnaphthalen-2-ol features a naphthalene core with a hydroxyl group at position 2 and a methyl substituent at position 3, delivering enhanced solubility and stability compared to unsubstituted analogs. This configuration enables selective reactivity in electrophilic substitution and facilitates incorporation into functionalized aromatic scaffolds for pharmaceutical and materials applications.

Application

3-Methylnaphthalen-2-ol serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the aromatic ring and hydroxyl position. Its stability under standard reaction conditions facilitates subsequent derivatization, including etherification, acylation, and coupling reactions. The methyl group enhances regioselectivity in electrophilic substitution, while the phenolic functionality supports metal-catalyzed transformations. This compound functions effectively in the construction of biologically relevant heterocyclic scaffolds and advanced intermediates for medicinal chemistry applications.

Synthesis

  • Route1
    • 3-(Hydroxymethyl)naphthalen-2-ol|CS-0517285
      30159-70-7
    • ~%
    • In-stock
      3-Methylnaphthalen-2-ol|CS-0145779
      17324-04-8

    References

    • Miller et al. Journal of the American Chemical Society, 1954 , vol. 76, p. 296
  • Route2
    • null|null
      96964-52-2
    • ~94%
    • In-stock
      3-Methylnaphthalen-2-ol|CS-0145779
      17324-04-8

    References

    • Ghera, Eugene; Ben-David, Yoshua Journal of Organic Chemistry, 1985 , vol. 50, # 18 p. 3355 - 3359
  • Route3
    • 2-Methoxy-3-methylnaphthalene|CS-0211918
      61873-80-1
    • ~%
    • In-stock
      3-Methylnaphthalen-2-ol|CS-0145779
      17324-04-8

    References

    • Huisgen; Nakaten Justus Liebigs Annalen der Chemie, 1954 , vol. 586, p. 84,107

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.85382
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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