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CRBN ligand-734

  • CAS No. 2654830-24-5

  • Cat. No. CS-0694320
  • Molecule weight388.14
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

CRBN ligand-734|CS-0694320

Structure of 2654830-24-5

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General Information

  • CAS No. 2654830-24-5
  • Cat. No. CS-0694320
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₀FIN₄O₂
  • Molecular Weight 388.14
  • Synonym(s) None
  • SMILES O=C1NC(=O)CCN1C2=NN(C=3C=C(I)C(F)=CC23)C

Description

1-(5-Fluoro-6-iodo-1-methyl-1H-indazol-3-yl)-2,4(1H,3H)-pyrimidinedione is a modular heterocyclic scaffold featuring a reactive iodine handle and a dihydropyrimidinedione core. This combination enables efficient cross-coupling transformations and facilitates integration into bioactive molecular architectures under standard conditions.

Application

1-(5-Fluoro-6-iodo-1-methyl-1H-indazol-3-yl)-2,4(1H,3H)-pyrimidinedione serves as a versatile building block for constructing bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions due to its iodide functionality. The pyrimidinedione core provides enhanced solubility and stability, facilitating purification and integration into complex scaffolds relevant to medicinal chemistry campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   67.23
  • LogP   1.7633
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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