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(R)-4-(tert-Butyl)-2-(Quinolin-2-yl)-4,5-dihydrooxazole

  • CAS No. 2634687-57-1

  • Cat. No. CS-0104438
  • Molecule weight254.33
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-4-(tert-Butyl)-2-(Quinolin-2-yl)-4,5-dihydrooxazole|CS-0104438

Structure of 2634687-57-1

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General Information

  • CAS No. 2634687-57-1
  • Cat. No. CS-0104438
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₈N₂O
  • Molecular Weight 254.33
  • Synonym(s) None
  • SMILES CC(C)(C)[C@H](CO1)N=C1C2=NC3=CC=CC=C3C=C2

Description

This chiral oxazole features a tert-butyl group and a quinolin-2-yl moiety, enabling robust integration into complex molecular architectures. The fused dihydrooxazole ring system imparts enhanced stability and defined stereochemistry, facilitating its use in asymmetric synthesis and medicinal chemistry applications.

Application

(R)-4-(tert-Butyl)-2-(quinolin-2-yl)-4,5-dihydrooxazole serves as a versatile chiral building block in medicinal chemistry, enabling the construction of complex heterocyclic scaffolds. Its dihydrooxazole core exhibits robust bench stability and tolerates a range of functional groups, facilitating downstream transformations such as oxidation, reduction, and transition-metal-catalyzed coupling reactions. The quinolinyl moiety provides a privileged pharmacophore for bioactive molecule design, while the (R)-configured tert-butyl group ensures stereochemical integrity during synthetic manipulations.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   34.48
  • LogP   3.4263
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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