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6-Fluoro-5-methylnicotinonitrile

  • CAS No. 261625-67-6

  • Cat. No. CS-0044044
  • Molecule weight136.13
  • Purity≥95%
  • MDL No.MFCD03095095

*For research and further manufacturing use only, not for direct human use.

6-Fluoro-5-methylnicotinonitrile|CS-0044044

Structure of 261625-67-6

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General Information

  • CAS No. 261625-67-6
  • Cat. No. CS-0044044
  • Purity ≥95%
  • MDL No. MFCD03095095
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FN₂
  • Molecular Weight 136.13
  • Synonym(s) 5-Cyano-2-fluoro-3-picoline
  • SMILES N#CC1=CN=C(F)C(C)=C1

Description

6-Fluoro-5-methylnicotinonitrile features a trifunctional pyridine core with fluorine, methyl, and nitrile groups positioned for strategic electronic modulation. This electron-deficient heterocycle integrates readily into synthetic sequences requiring orthogonal reactivity, offering enhanced solubility and stability under standard conditions.

Application

6-Fluoro-5-methylnicotinonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds. Its ortho-fluorine and nitrile groups facilitate nucleophilic aromatic substitution and downstream functionalization, while the methyl group provides a handle for oxidation or further derivatization. The compound exhibits good bench stability and is compatible with standard coupling reactions, making it well-suited for use in API synthesis and target-oriented library development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 3439
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H331-H335
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.4008
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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