Lot numbers can be found on the outside label of a product:
Morpholine-4-sulfonamide
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CAS No. 25999-04-6
- Cat. No. CS-0048862
- Purity≥95%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 25999-04-6
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General Information
- CAS No. 25999-04-6
- Cat. No. CS-0048862
- Purity ≥95%
- MDL No. None
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₁₀N₂O₃S
- Molecular Weight 166.20
- Synonym(s) 4-Morpholinesulfonamide
- SMILES NS(=O)(=O)N1CCOCC1
Description
Morpholine-4-sulfonamide features a morpholine ring tethered to a sulfonamide group, delivering enhanced solubility and metabolic stability. This scaffold integrates readily into medicinal chemistry libraries, offering a polar, hydrogen-bond-capable moiety for optimizing pharmacokinetic profiles in bioactive compound design.
Application
Morpholine-4-sulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of sulfonamide-containing heterocycles common in kinase inhibitors and other bioactive scaffolds. Its well-defined reactivity facilitates nucleophilic substitution and coupling reactions under standard conditions, with good bench stability and ease of purification. The morpholine ring provides favorable solubility and metabolic properties, enhancing its utility in lead optimization campaigns.
Synthesis
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Route1
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1048017-38-4 - ~99%
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In-stock
25999-04-6
References
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Tawaraishi, Taisuke; Imoto, Hiroshi; Cho, Nobuo Patent: US2008/194617 A1, 2008 ; Location in patent: Page/Page column 72 ;
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Route2
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861397-54-8
- ~99%
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In-stock
25999-04-6
References
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Bristol-Myers Squibb Company Patent: US2007/78122 A1, 2007 ; Location in patent: Page/Page column 177 ; US 20070078122 A1
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Route3
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110-91-8
- ~91%
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In-stock
25999-04-6
References
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Hedayatullah, Mir; Hugueny, Jean Claude Phosphorus and Sulfur and the Related Elements, 1985 , vol. 25, p. 33 - 38
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 72.63
- LogP -1.4779
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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