Lot numbers can be found on the outside label of a product:
Morpholine-4-sulfonyl chloride
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CAS No. 1828-66-6
- Cat. No. CS-W001907
- Purity≥98%
- MDL No.MFCD03249981
*For research and further manufacturing use only, not for direct human use.
Structure of 1828-66-6
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General Information
- CAS No. 1828-66-6
- Cat. No. CS-W001907
- Purity ≥98%
- MDL No. MFCD03249981
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₈ClNO₃S
- Molecular Weight 185.63
- Synonym(s) Morpholinosulfonyl chloride
- SMILES ClS(=O)(=O)N1CCOCC1
Description
Morpholine-4-sulfonyl chloride serves as a reactive sulfonamide acylating agent, enabling direct installation of sulfonyl groups onto nucleophiles. This bench-stable reagent features high functional group tolerance and facilitates efficient coupling under mild conditions, streamlining synthesis in medicinal chemistry and materials science applications.
Application
Morpholine-4-sulfonyl chloride serves as a versatile sulfonylating agent for the selective introduction of the morpholine-4-sulfonyl group into organic substrates. It facilitates efficient amide and sulfonamide formation under mild conditions, exhibits good bench stability, and enables straightforward purification due to its reactivity profile. This reagent is particularly valuable in medicinal chemistry for constructing sulfonamide-containing scaffolds and modulating physicochemical properties in API development.
Synthesis
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Route1
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110-91-8 - ~99%
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In-stock
1828-66-6
References
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GILEAD SCIENCES, INC.; CAI, Zhenhong, R.; CHEN, Xiaowu; FARDIS, Maria; JABRI, Salman, Y.; JIN, Haolun; KIM, Choung, U.; METOBO, Sanuel, E.; MISH, Michael, R.; PASTOR, Richard, M. Patent: WO2005/117904 A2, 2005 ; Location in patent: Page/Page column 463-464 ;
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Route2
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108085-16-1
- ~%
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In-stock
1828-66-6
References
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WO2006/77414 A1, ; Page/Page column 170-171 ; WO 2006/077414 A1
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Route3
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110-91-8
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7791-25-5
- ~99%
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In-stock
1828-66-6
References
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Gilead Sciences, Inc. Patent: WO2004/35576 A2, 2004 ; Location in patent: Page 227 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 46.61
- LogP -0.1978
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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