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CS-W001157 4
Total: USD 88.00

Piperidine-1-sulfonyl chloride

  • CAS No. 35856-62-3

  • Cat. No. CS-W019289
  • Purity≥97%
  • MDL No.MFCD03250329

*For research and further manufacturing use only, not for direct human use.

Piperidine-1-sulfonyl chloride|CS-W019289

Structure of 35856-62-3

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General Information

  • CAS No. 35856-62-3
  • Cat. No. CS-W019289
  • Purity ≥97%
  • MDL No. MFCD03250329
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀ClNO₂S
  • Molecular Weight 183.66
  • Synonym(s) Piperidinosulfonyl chloride
  • SMILES ClS(=O)(=O)N1CCCCC1

Description

Piperidine-1-sulfonyl chloride delivers a reactive sulfonyl electrophile for direct functionalization of nucleophiles in synthetic workflows. This bench-stable reagent integrates efficiently into amine-based transformations, enabling rapid access to sulfonamide derivatives with high chemoselectivity under mild conditions.

Application

Piperidine-1-sulfonyl chloride serves as a versatile sulfonylating agent for the efficient installation of sulfonamide groups under mild conditions. Its reactivity enables selective transformation of amines and alcohols, offering robust functional group tolerance and facile purification. The compound functions reliably in the synthesis of sulfonamide-containing heterocycles and bioactive scaffolds, with excellent bench stability and compatibility in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      110-89-4
    • ~63%
    • In-stock
      Piperidine-1-sulfonyl chloride|CS-W019289
      35856-62-3

    References

    • Padma, D. K.; Bhat, V. Subrahmanya; Murthy, A. R. Vasudeva Journal of Fluorine Chemistry, 1982 , vol. 20, p. 425 - 438
  • Route2
    • null|null
      110-89-4
    • ~62%
    • In-stock
      Piperidine-1-sulfonyl chloride|CS-W019289
      35856-62-3
    • null|null
      6091-44-7

    References

    • Journal of the American Chemical Society, , vol. 135, # 29 p. 10638 - 10641
  • Route3
    • null|null
      6091-44-7
    • ~%
    • In-stock
      Piperidine-1-sulfonyl chloride|CS-W019289
      35856-62-3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 24 p. 3075 - 3080

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.38
  • LogP   0.9559
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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