6-Chloro-7-fluoro-1H-indole-2-carboxylic acid

Name: 6-Chloro-7-fluoro-1H-indole-2-carboxylic acid
Brand: ChemScene
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CAS No. 259860-07-6
Cat. No. CS-0311521
Purity≥97%
MDL No.MFCD22563677

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-7-fluoro-1H-indole-2-carboxylic acid|CS-0311521

Structure of 259860-07-6

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General Information

CAS No. 259860-07-6
Cat. No. CS-0311521
Purity ≥97%
MDL No. MFCD22563677
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₅ClFNO₂
Molecular Weight 213.59
Synonym(s) None
SMILES O=C(C(N1)=CC2=C1C(F)=C(Cl)C=C2)O

Description

6-Chloro-7-fluoro-1H-indole-2-carboxylic acid is a fluorinated indole derivative featuring complementary halogen substituents at the 6- and 7-positions, enhancing electronic modulation and metabolic stability. This bench-stable scaffold integrates readily into diverse synthetic routes for medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

6-Chloro-7-fluoro-1H-indole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of indole-based scaffolds through standard amide coupling and electrophilic substitution reactions. Its orthogonal halogenation pattern provides predictable reactivity for late-stage functionalization, while the carboxylic acid group facilitates direct derivatization or salt formation. Bench-stable and compatible with common purification methods, it functions reliably in multi-step synthesis workflows.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 53.09
LogP 2.6586
H_Acceptors 1
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

Key Words

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6-Chloro-7-fluoro-1H-indole-2-carboxylic acid

CAS No. 259860-07-6

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