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CS-W001157 4
Total: USD 88.00

(2-Hydroxy-3-methoxyphenyl)boronic acid

  • CAS No. 259209-17-1

  • Cat. No. CS-0174142
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2-Hydroxy-3-methoxyphenyl)boronic acid|CS-0174142

Structure of 259209-17-1

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General Information

  • CAS No. 259209-17-1
  • Cat. No. CS-0174142
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉BO₄
  • Molecular Weight 167.95
  • Synonym(s) 3-METHOXY-2-HYDROXYPHENYL BORONIC ACID
  • SMILES COC1=CC=CC(B(O)O)=C1O

Description

This boronic acid features a hydroxyl and methoxy group ortho to the boronate, enhancing solubility and stability. The phenolic OH enables hydrogen bonding and facilitates coupling reactions under mild conditions. Designed for efficient Suzuki-Miyaura cross-coupling in complex molecule synthesis, this reagent combines predictable reactivity with bench-stable handling.

Application

(2-Hydroxy-3-methoxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. Its ortho-hydroxyl and methoxy substituents provide enhanced solubility and stability compared to unsubstituted analogs, while maintaining compatibility with standard reaction conditions. The molecule facilitates direct functionalization of complex scaffolds and supports iterative synthesis workflows in medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   69.92
  • LogP   -0.9194
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   2

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