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CS-W001157 4
Total: USD 88.00

(5-Fluoro-2-(hydroxymethyl)phenyl)boronic acid

  • CAS No. 1246633-53-3

  • Cat. No. CS-0044908
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(5-Fluoro-2-(hydroxymethyl)phenyl)boronic acid|CS-0044908

Structure of 1246633-53-3

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General Information

  • CAS No. 1246633-53-3
  • Cat. No. CS-0044908
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BFO₃
  • Molecular Weight 169.95
  • Synonym(s) 5-Fluoro-2-hydroxymethylphenylboronic acid
  • SMILES OCC1=CC=C(F)C=C1B(O)O

Description

This boronate moiety features a para-fluoro substituent and a hydroxymethyl group on the phenyl ring, enhancing solubility and enabling direct functionalization. The compound serves as a key building block in Suzuki-Miyaura couplings, offering stable performance under standard conditions with predictable reactivity.

Application

(5-Fluoro-2-(hydroxymethyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-fluoro substituent enhances reactivity and provides a handle for further functionalization. Its stability, ease of handling, and compatibility with diverse reaction partners make it a practical choice for constructing biaryl motifs in pharmaceutical and agrochemical synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -1.0022
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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