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Boronic acid, B-[5-(hydroxymethyl)-3-thienyl]-

  • CAS No. 1268683-45-9

  • Cat. No. CS-0029511
  • Purity≥95%
  • MDL No.MFCD21363061

*For research and further manufacturing use only, not for direct human use.

Boronic acid, B-[5-(hydroxymethyl)-3-thienyl]-|CS-0029511

Structure of 1268683-45-9

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General Information

  • CAS No. 1268683-45-9
  • Cat. No. CS-0029511
  • Purity ≥95%
  • MDL No. MFCD21363061
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇BO₃S
  • Molecular Weight 157.98
  • Synonym(s) 5-(hydroxymethyl)thiophen-3-boronicacid
  • SMILES OCC1=CC(B(O)O)=CS1

Description

This boronate moiety integrates a hydroxymethyl-functionalized thiophene scaffold, enabling efficient cross-coupling under standard conditions. The pendant hydroxyl group enhances solubility and facilitates downstream derivatization, while the boronic acid functionality ensures compatibility with Suzuki-Miyaura reactions.

Application

(5-(Hydroxymethyl)thiophen-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The boronic acid moiety exhibits good bench stability and tolerates a range of functional groups, facilitating straightforward purification and integration into complex molecular scaffolds common in medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -1.0798
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   2

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