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CS-W001157 4
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2-Oxoindoline-7-carboxylic acid

  • CAS No. 25369-43-1

  • Cat. No. CS-0053844
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Oxoindoline-7-carboxylic acid|CS-0053844

Structure of 25369-43-1

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General Information

  • CAS No. 25369-43-1
  • Cat. No. CS-0053844
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇NO₃
  • Molecular Weight 177.16
  • Synonym(s) OXO-INDOLINE-7-CARBOXYLIC ACID
  • SMILES O=C(C1=CC=CC2=C1NC(C2)=O)O

Description

2-Oxoindoline-7-carboxylic acid features a fused indoline core with a ketone at the 2-position and a carboxylic acid at the 7-position, enabling direct integration into bioactive molecule scaffolds. This electron-deficient heterocycle supports diverse synthetic transformations under mild conditions, offering high stability and compatibility with standard peptide coupling protocols.

Application

2-Oxoindoline-7-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient construction of indoline-based heterocycles. Its ortho-ketone and carboxylic acid functionalities support diverse transformations, including reductive amination, amide coupling, and cyclization reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns targeting kinase inhibitors and CNS-active scaffolds.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1302 - 1306

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.4
  • LogP   0.8794
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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