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(6-Fluoropyridin-2-yl)methanamine dihydrochloride

  • CAS No. 1257535-08-2

  • Cat. No. CS-0043034
  • Molecule weight199.05
  • Purity≥95%
  • MDL No.MFCD16872044

*For research and further manufacturing use only, not for direct human use.

(6-Fluoropyridin-2-yl)methanamine dihydrochloride|CS-0043034

Structure of 1257535-08-2

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General Information

  • CAS No. 1257535-08-2
  • Cat. No. CS-0043034
  • Purity ≥95%
  • MDL No. MFCD16872044
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉Cl₂FN₂
  • Molecular Weight 199.05
  • Synonym(s) (6-fluoropyridin-2-yl)methanamine,dihydrochloride
  • SMILES NCC1=NC(F)=CC=C1.[H]Cl.[H]Cl

Description

This bench-stable dihydrochloride salt features a fluoropyridine core paired with a primary amine handle, enabling straightforward conjugation and metal coordination. The para-fluorine enhances electrophilicity for nucleophilic substitution, while the protonated amine ensures solubility in polar solvents. Ideal for building bioactive scaffolds and catalyst ligands under standard conditions.

Application

(6-Fluoropyridin-2-yl)methanamine dihydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient construction of fluorinated heterocyclic scaffolds. Its bench-stable dihydrochloride salt form enhances handling and solubility, facilitating direct use in amide couplings, Suzuki-Miyaura cross-couplings, and nucleophilic substitution reactions. The ortho-fluoro group provides a latent site for further functionalization, while the primary amine functions as a key synthetic handle for diversification in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.523
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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