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CS-W001157 4
Total: USD 88.00

1-Bromo-4-(1-(trifluoromethyl)cyclopropyl)benzene

  • CAS No. 1227160-18-0

  • Cat. No. CS-0147256
  • Molecule weight265.07
  • Purity≥98%
  • MDL No.MFCD16817615

*For research and further manufacturing use only, not for direct human use.

1-Bromo-4-(1-(trifluoromethyl)cyclopropyl)benzene|CS-0147256

Structure of 1227160-18-0

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General Information

  • CAS No. 1227160-18-0
  • Cat. No. CS-0147256
  • Purity ≥98%
  • MDL No. MFCD16817615
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈BrF₃
  • Molecular Weight 265.07
  • Synonym(s) 1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene
  • SMILES FC(C1(C2=CC=C(Br)C=C2)CC1)(F)F

Description

1-Bromo-4-(1-(trifluoromethyl)cyclopropyl)benzene features a trifluoromethyl-cyclopropyl substituent that imparts enhanced metabolic stability and lipophilicity, making it valuable for medicinal chemistry. The bromine handle enables efficient cross-coupling reactions under standard conditions, facilitating the rapid assembly of complex aryl architectures in drug discovery pipelines.

Application

1-Bromo-4-(1-(trifluoromethyl)cyclopropyl)benzene serves as a versatile aryl halide building block for Suzuki-Miyaura and Negishi coupling reactions, enabling efficient construction of biaryl scaffolds. The trifluoromethylcyclopropyl group imparts enhanced metabolic stability and lipophilicity, making it valuable in medicinal chemistry. Its bench-stable nature and compatibility with standard cross-coupling conditions facilitate reliable synthesis of complex functionalized arenes.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   4.043
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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