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3-(1,1,1,5,5,5-Hexamethyl-3-((trimethylsilyl)oxy)trisiloxan-3-yl)propan-1-amine

  • CAS No. 25357-81-7

  • Cat. No. CS-0535133
  • Purity≥98%
  • MDL No.MFCD00054848

*For research and further manufacturing use only, not for direct human use.

3-(1,1,1,5,5,5-Hexamethyl-3-((trimethylsilyl)oxy)trisiloxan-3-yl)propan-1-amine|CS-0535133

Structure of 25357-81-7

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General Information

  • CAS No. 25357-81-7
  • Cat. No. CS-0535133
  • Purity ≥98%
  • MDL No. MFCD00054848
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₃₅NO₃Si₄
  • Molecular Weight 353.75
  • Synonym(s) 3-Aminopropyltris(trimethylsiloxy)silane
  • SMILES C[Si](C)(C)O[Si](CCCN)(O[Si](C)(C)C)O[Si](C)(C)C

Description

This trisiloxane-functional amine features a sterically shielded, moisture-tolerant siloxy-protected backbone that enables stable incorporation into polymer architectures. The hexamethyl-substituted trisiloxane moiety imparts enhanced hydrophobicity and thermal resilience, while the terminal primary amine facilitates coupling reactions under mild conditions.

Application

3-(1,1,1,5,5,5-Hexamethyl-3-((trimethylsilyl)oxy)trisiloxan-3-yl)propan-1-amine serves as a robust, bench-stable silyl-protected amine building block, enabling efficient late-stage functionalization in complex molecule synthesis. Its trisiloxane backbone confers excellent solubility and stability under standard reaction conditions, while the trimethylsilyl ether group facilitates selective deprotection. This compound functions as a versatile scaffold for constructing nitrogen-containing heterocycles and peptide analogs, offering high functional group tolerance and compatibility with common coupling protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   53.71
  • LogP   3.8286
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   9

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