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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid

  • CAS No. 252049-14-2

  • Cat. No. CS-0154637
  • Purity≥98%
  • MDL No.MFCD02094467

*For research and further manufacturing use only, not for direct human use.

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid|CS-0154637

Structure of 252049-14-2

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General Information

  • CAS No. 252049-14-2
  • Cat. No. CS-0154637
  • Purity ≥98%
  • MDL No. MFCD02094467
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₈H₂₉NO₄
  • Molecular Weight 443.53
  • Synonym(s) Fmoc-D-4-tetr-Butylphenylalanine
  • SMILES CC(C)(C1=CC=C(C[C@@H](NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)C(O)=O)C=C1)C

Description

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid is a chiral building block featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group and a sterically hindered aryl side chain. This configuration enables efficient incorporation into peptide synthesis workflows, where the Fmoc moiety facilitates orthogonal deprotection under mild basic conditions. The para-tert-butylphenyl group provides enhanced solubility and stability during handling.

Application

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid serves as a robust chiral building block for peptide synthesis, offering enhanced stability and ease of purification. The Fmoc group enables efficient orthogonal deprotection, while the bulky tert-butyl aryl substituent provides steric shielding and favorable solubility. This amino acid derivative facilitates reliable coupling in solid-phase and solution-phase methodologies, supporting scalable access to complex peptidomimetics and bioactive scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   5.5185
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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