Fmoc-D-Bip(4,4’)-OH

Name: Fmoc-D-Bip(4,4’)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 205526-38-1
Cat. No. CS-W011554
Purity≥97%
MDL No.MFCD00191199

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 205526-38-1

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General Information

CAS No. 205526-38-1
Cat. No. CS-W011554
Purity ≥97%
MDL No. MFCD00191199
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₀H₂₅NO₄
Molecular Weight 463.52
Synonym(s) None
SMILES O=C(O)[C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)CC4=CC=C(C5=CC=CC=C5)C=C4

Description

Fmoc-D-Bip(4,4’)-OH features a D-configured biphenyl scaffold bearing hydroxyl groups at the 4,4’ positions, enabling direct incorporation into peptide chains. The Fmoc group facilitates efficient solid-phase synthesis, while the rigid, electron-rich biphenyl motif enhances structural stability and modulates conformational dynamics in bioactive sequences.

Application

Fmoc-D-Bip(4,4’)-OH serves as a robust building block for peptide synthesis, enabling the incorporation of sterically hindered, aromatic side chains with enhanced stability. Its D-configured biphenyl moiety offers improved metabolic resistance and conformational rigidity, facilitating the construction of challenging peptidomimetics and macrocyclic scaffolds. The Fmoc group ensures convenient orthogonal protection and efficient removal under standard conditions, while the phenolic hydroxyl supports downstream derivatization.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 75.63
LogP 5.888
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 7

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Alanine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-D-Bip(4,4’)-OH

CAS No. 205526-38-1

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