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CS-W001157 4
Total: USD 88.00

6-Phenoxypyridin-3-amine

  • CAS No. 25194-67-6

  • Cat. No. CS-0450365
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Phenoxypyridin-3-amine|CS-0450365

Structure of 25194-67-6

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General Information

  • CAS No. 25194-67-6
  • Cat. No. CS-0450365
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀N₂O
  • Molecular Weight 186.21
  • Synonym(s) IFLAB-BB F2108-0094
  • SMILES C1=CC=C(C=C1)OC2=NC=C(C=C2)N

Description

6-Phenoxypyridin-3-amine features a pyridine core functionalized with a phenoxyl group at C6 and an amine at C3, enabling strong hydrogen bonding and π-stacking interactions. This scaffold integrates electron-rich aromatic systems with polar amine functionality, enhancing solubility and binding versatility in medicinal chemistry applications.

Application

6-Phenoxypyridin-3-amine serves as a versatile building block for medicinal chemistry and materials science, enabling efficient construction of bioactive heterocycles. Its pyridin-3-amine core supports diverse functionalization, while the phenoxyl substituent enhances solubility and modulates electronic properties. The molecule exhibits excellent bench stability and compatibility with standard coupling reactions, facilitating straightforward incorporation into complex scaffolds via C–N and C–O bond formations.

Synthesis

  • Route1
    • 5-Nitro-2-phenoxypyridine|CS-0333371
      28222-02-8
    • ~85%
    • In-stock
      6-Phenoxypyridin-3-amine|CS-0450365
      25194-67-6

    References

    • KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY Patent: WO2009/125923 A2, 2009 ; Location in patent: Page/Page column 37-38 ; WO 2009/125923 A2
  • Route2

    References

    • US6503949 B1, ; US 6503949 B1
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 32, # 3 p. 583 - 593

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   2.4561
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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