2'-O-MOE-rC

Name: 2'-O-MOE-rC
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 251647-54-8
Cat. No. CS-0608886
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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General Information

CAS No. 251647-54-8
Cat. No. CS-0608886
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄₉H₅₈N₅O₁₀P
Molecular Weight 907.99
Synonym(s) None
SMILES COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OCCOC)[C@H](N5C(N=C(NC(C6=CC=CC=C6)=O)C=C5)=O)O4

Description

2'-O-MOE-rC combines a 2'-O-methoxyethyl modification with a ribocytidine scaffold, delivering enhanced nuclease resistance and improved binding affinity. This modified nucleoside integrates seamlessly into antisense oligonucleotides, enabling stable duplex formation under physiological conditions.

Application

2'-O-MOE-rC serves as a robust nucleoside building block for antisense oligonucleotide synthesis, offering enhanced nuclease resistance and improved binding affinity due to the 2'-O-methoxyethyl modification. Its stability under physiological conditions facilitates reliable incorporation into therapeutic sequences, while its compatibility with standard phosphoramidite chemistry enables efficient solid-phase synthesis and straightforward purification.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 164.86
LogP 8.11168
H_Acceptors 14
H_Donors 1
Rotatable_Bonds 23

Other Classifications

Life Science Nucleosides & Nucleotides Nucleosides, Deoxyribonucleosides and Other Nucleosides

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Nucleoside Phosphoramidites

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry Nucleoside Phosphoramidites

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2'-O-MOE-rC

CAS No. 251647-54-8

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