2'-O-MOE-5-Me-C(Bz)

Name: 2'-O-MOE-5-Me-C(Bz)
Brand: ChemScene
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CAS No. 163759-94-2
Cat. No. CS-0608893
Purity≥97%
MDL No.MFCD28009446

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 163759-94-2
Cat. No. CS-0608893
Purity ≥97%
MDL No. MFCD28009446
Storage -20°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅₀H₆₀N₅O₁₀P
Molecular Weight 922.01
Synonym(s) None
SMILES COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OCCOC)[C@H](N5C(N=C(NC(C6=CC=CC=C6)=O)C(C)=C5)=O)O4

Description

2'-O-MOE-5-Me-C(Bz) features a 2'-O-methoxyethyl modification paired with a 5-methylcytosine base bearing a benzoyl group, delivering enhanced nuclease resistance and improved binding affinity. This modified nucleoside integrates seamlessly into oligonucleotide synthesis workflows, enabling stable, high-affinity duplex formation for therapeutic and diagnostic applications.

Application

2'-O-MOE-5-Me-C(Bz) serves as a versatile nucleoside building block for antisense oligonucleotide synthesis, combining the nuclease resistance of 2'-O-methoxyethyl (MOE) modification with the enhanced binding affinity from 5-methylcytidine. The benzoyl group at the C5 position provides orthogonal protection during solid-phase synthesis, enabling selective deprotection and efficient incorporation into therapeutic oligonucleotide sequences. Its bench-stable nature and compatibility with standard coupling protocols facilitate scalable production and reliable purification.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

Quality Control

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Computational Chemistry Data

TPSA 164.86
LogP 8.4201
H_Acceptors 14
H_Donors 1
Rotatable_Bonds 23

Other Classifications

Life Science Nucleosides & Nucleotides Nucleosides, Deoxyribonucleosides and Other Nucleosides

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Nucleoside Phosphoramidites

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry Nucleoside Phosphoramidites

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

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2'-O-MOE-5-Me-C(Bz)

CAS No. 163759-94-2

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