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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-aminopropanoic acid

  • CAS No. 251317-00-7

  • Cat. No. CS-0101042
  • Purity≥98%
  • MDL No.MFCD01318733

*For research and further manufacturing use only, not for direct human use.

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-aminopropanoic acid|CS-0101042

Structure of 251317-00-7

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General Information

  • CAS No. 251317-00-7
  • Cat. No. CS-0101042
  • Purity ≥98%
  • MDL No. MFCD01318733
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₁₈N₂O₄
  • Molecular Weight None
  • Synonym(s) FMOC-D-DAP-OH HCL
  • SMILES O=C(O)[C@@H](CN)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-aminopropanoic acid is a chiral building block featuring a fluorenylmethyl carbamate (Fmoc) protected amine and a β-amino acid scaffold. This configuration enables direct incorporation into peptide sequences during solid-phase synthesis, offering enhanced solubility and compatibility with standard coupling protocols. The Fmoc group provides orthogonal protection, facilitating selective deprotection under mild basic conditions.

Application

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-aminopropanoic acid serves as a valuable chiral building block in peptide synthesis, enabling the incorporation of (R)-homophenylalanine derivatives. The fluorenylmethoxycarbonyl (Fmoc) group provides excellent stability and orthogonal deprotection under mild basic conditions, while the α-amine and β-amino functionalities support diverse coupling reactions. Its bench-stable solid form and compatibility with standard SPPS workflows facilitate efficient access to complex peptide architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   101.65
  • LogP   1.937
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   5

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