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CS-W001157 4
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Fmoc-Dap-OH

  • CAS No. 181954-34-7

  • Cat. No. CS-W013939
  • Purity≥96%
  • MDL No.MFCD00237019

*For research and further manufacturing use only, not for direct human use.

Fmoc-Dap-OH|CS-W013939

Structure of 181954-34-7

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General Information

  • CAS No. 181954-34-7
  • Cat. No. CS-W013939
  • Purity ≥96%
  • MDL No. MFCD00237019
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₁₈N₂O₄
  • Molecular Weight 326.35
  • Synonym(s) 3-amino-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine
  • SMILES O=C([C@@H](NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)CN)O

Description

Fmoc-Dap-OH is a key building block for solid-phase peptide synthesis, featuring a dibenzofulvene-protected lysine derivative with a pendant primary amine. This orthogonal functionality enables selective side-chain derivatization and incorporation into cyclic or branched peptides. The Fmoc group ensures stable protection under standard deprotection conditions, while the hydroxylated side chain supports efficient conjugation chemistries in bioconjugation workflows.

Synthesis

  • Route1

    References

    • Akaji, Kenichi; Aimoto, Saburou Tetrahedron, 2001 , vol. 57, # 9 p. 1749 - 1755
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 124, # 38 p. 11272 - 11273

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   101.65
  • LogP   1.937
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   5

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