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CS-W001157 4
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5-Bromo-3-fluoro-2-hydroxybenzaldehyde

  • CAS No. 251300-28-4

  • Cat. No. CS-W004466
  • Purity≥98%
  • MDL No.MFCD03788530

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-fluoro-2-hydroxybenzaldehyde|CS-W004466

Structure of 251300-28-4

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General Information

  • CAS No. 251300-28-4
  • Cat. No. CS-W004466
  • Purity ≥98%
  • MDL No. MFCD03788530
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrFO₂
  • Molecular Weight 219.01
  • Synonym(s) 5-Bromo-3-fluorosalicylaldehyde
  • SMILES O=CC1=CC(Br)=CC(F)=C1O

Description

5-Bromo-3-fluoro-2-hydroxybenzaldehyde features a unique trifunctional aromatic core integrating bromo, fluoro, and phenolic hydroxyl groups adjacent to an aldehyde. This electron-deficient scaffold enables selective coupling in cross-coupling and cyclization reactions. The ortho-hydroxyaldehyde motif facilitates chelation in transition metal catalysis and supports rapid derivatization for bioactive molecule synthesis under standard conditions.

Synthesis

  • Route1

    References

    • BRISTOL-MYERS SQUIBB COMPANY; THOMPSON III, Lorin A.; SHI, Jianliang; WU, Yong-Jin; MARCIN, Lawrence R.; RAJAMANI, Ramkumar; HIGGINS, Mendi A. Patent: WO2012/162330 A1, 2012 ; Location in patent: Page/Page column 58 ;
  • Route2
    • In-stock
      4-Bromo-2-fluorophenol|CS-W004072
      2105-94-4
    • null|null
      100-97-0
    • ~80%
    • In-stock
      5-Bromo-3-fluoro-2-hydroxybenzaldehyde|CS-W004466
      251300-28-4

    References

    • Micklatcher, Mark L.; Cushman, Mark Synthesis, 1999 , # 11 p. 1878 - 1880

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.1063
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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