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CS-W001157 4
Total: USD 88.00

4-Bromo-2-fluorophenol

  • CAS No. 2105-94-4

  • Cat. No. CS-W004072
  • Purity≥95%
  • MDL No.MFCD00011722

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-fluorophenol|CS-W004072

Structure of 2105-94-4

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General Information

  • CAS No. 2105-94-4
  • Cat. No. CS-W004072
  • Purity ≥95%
  • MDL No. MFCD00011722
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrFO
  • Molecular Weight 191.00
  • Synonym(s) 2-Fluoro-4-bromophenol
  • SMILES OC1=C(F)C=C(Br)C=C1

Description

4-Bromo-2-fluorophenol features a fluorine atom at the ortho position relative to the hydroxyl group, enhancing electrophilic reactivity while maintaining stability under standard conditions. This electron-deficient aromatic scaffold enables efficient coupling in cross-coupling reactions and serves as a key building block for pharmaceutical intermediates and functional materials.

Application

4-Bromo-2-fluorophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki, Stille, or Negishi coupling, while the ortho-fluoro substituent enhances electrophilic substitution selectivity and modulates electronic properties. Its bench-stable crystalline form simplifies handling and purification, making it ideal for multi-step synthesis workflows requiring functional group tolerance and predictable regiochemistry.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.2938
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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