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CS-W001157 4
Total: USD 88.00

2,4,5-Trifluorophenylboronic acid

  • CAS No. 247564-72-3

  • Cat. No. CS-0007601
  • Purity≥98%
  • MDL No.MFCD01863165

*For research and further manufacturing use only, not for direct human use.

2,4,5-Trifluorophenylboronic acid|CS-0007601

Structure of 247564-72-3

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General Information

  • CAS No. 247564-72-3
  • Cat. No. CS-0007601
  • Purity ≥98%
  • MDL No. MFCD01863165
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BF₃O₂
  • Molecular Weight 175.90
  • Synonym(s) (2,4,5-Trifluorophenyl)boronic acid
  • SMILES FC1=C(F)C=C(F)C(B(O)O)=C1

Description

2,4,5-Trifluorophenylboronic acid features a trifluorinated aromatic ring that enhances electronic withdrawal and metabolic stability. This electron-deficient boronate moiety integrates efficiently into Suzuki-Miyaura coupling reactions under standard conditions. The compound exhibits bench-stable handling characteristics and delivers high functional group tolerance in complex molecule assembly.

Application

2,4,5-Trifluorophenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its trifluorinated aryl scaffold offers enhanced metabolic stability and improved lipophilicity, making it valuable for medicinal chemistry applications. The boronic acid exhibits excellent bench stability, facilitates straightforward purification, and demonstrates broad functional group tolerance in diverse synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   -0.2163
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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