Desamino lenalidomide-5-F

Name: Desamino lenalidomide-5-F
Brand: ChemScene
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CAS No. 2468780-76-7
Cat. No. CS-0181235
Purity≥97%
MDL No.MFCD34186457

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 2468780-76-7

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General Information

CAS No. 2468780-76-7
Cat. No. CS-0181235
Purity ≥97%
MDL No. MFCD34186457
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₁FN₂O₃
Molecular Weight 262.24
Synonym(s) None
SMILES O=C1NC(=O)C(N2C(=O)C3=CC=C(F)C=C3C2)CC1

Description

This fluorinated phthalimidine derivative integrates a reactive 5-fluoride moiety with a piperidinone core, enabling efficient conjugation in synthetic workflows. The electron-deficient aryl fluoride facilitates nucleophilic substitution under mild conditions, while the fused heterocyclic framework provides enhanced stability and precise spatial orientation for targeted molecular assembly.

Application

2-(2,6-Dioxopiperidin-3-yl)phthalimidine 5-fluoride serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted piperidine scaffolds through nucleophilic displacement. The 5-fluoro substituent enhances reactivity in C–N bond formation, facilitating the synthesis of complex heterocycles under mild conditions. Its bench-stable nature and compatibility with diverse functional groups make it suitable for iterative coupling strategies in API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 66.48
LogP 0.0398
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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Desamino lenalidomide-5-F

CAS No. 2468780-76-7

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