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CS-W001157 4
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5-Chloro-3-fluoropyridin-2-amine

  • CAS No. 246847-98-3

  • Cat. No. CS-W010989
  • Purity≥98%
  • MDL No.MFCD09878434

*For research and further manufacturing use only, not for direct human use.

5-Chloro-3-fluoropyridin-2-amine|CS-W010989

Structure of 246847-98-3

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General Information

  • CAS No. 246847-98-3
  • Cat. No. CS-W010989
  • Purity ≥98%
  • MDL No. MFCD09878434
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄ClFN₂
  • Molecular Weight 146.55
  • Synonym(s) 2-Amino-5-chloro-3-fluoropyridine
  • SMILES FC1=CC(Cl)=CN=C1N

Description

5-Chloro-3-fluoropyridin-2-amine features a trifunctional pyridine core with strategically positioned chlorine and fluorine substituents, enabling precise electronic tuning. The amino group at C2 provides a reactive handle for cross-coupling and amide formation. This bench-stable, moisture-tolerant scaffold integrates efficiently into bioactive molecule design.

Application

5-Chloro-3-fluoropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 2-position via nucleophilic substitution or transition-metal-catalyzed coupling. Its orthogonal reactivity profile—combining a latent amine with two distinct halogen handles—facilitates sequential diversification in API synthesis. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for high-throughput screening campaigns and process development workflows.

Synthesis

  • Route1
    • 5-Chloro-3-fluoro-2-hydrazinylpyridine|CS-0450321
      248255-70-1
    • ~%
    • In-stock
      5-Chloro-3-fluoropyridin-2-amine|CS-W010989
      246847-98-3

    References

    • US2006/47124 A1, ; Page/Page column 4 ; US 20060047124 A1
  • Route2

    References

    • US2008/242695 A1, ; Page/Page column 34 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS09
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331-H319-H410
Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P361+P364-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.4563
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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