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CS-W001157 4
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5-Chloro-3-fluoro-2-nitropyridine

  • CAS No. 1064783-29-4

  • Cat. No. CS-W018984
  • Purity≥95%
  • MDL No.MFCD19690192

*For research and further manufacturing use only, not for direct human use.

5-Chloro-3-fluoro-2-nitropyridine|CS-W018984

Structure of 1064783-29-4

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General Information

  • CAS No. 1064783-29-4
  • Cat. No. CS-W018984
  • Purity ≥95%
  • MDL No. MFCD19690192
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂ClFN₂O₂
  • Molecular Weight 176.53
  • Synonym(s) None
  • SMILES O=[N+](C1=NC=C(Cl)C=C1F)[O-]

Description

5-Chloro-3-fluoro-2-nitropyridine is a fluorinated, chlorinated pyridine derivative featuring a nitro group at the 2-position. This electron-deficient heterocycle integrates seamlessly into cross-coupling reactions and serves as a key intermediate in medicinal chemistry. The ortho-nitro group enables direct functionalization, while the flanking halogens facilitate palladium-catalyzed transformations under standard conditions.

Application

5-Chloro-3-fluoro-2-nitropyridine serves as a versatile building block for the synthesis of functionalized pyridine derivatives, enabling direct substitution at C5 and C3 via palladium-catalyzed cross-coupling or nucleophilic aromatic substitution. Its ortho-difunctionalized structure provides high reactivity and selectivity in late-stage diversification, facilitating access to complex heterocyclic scaffolds relevant to medicinal chemistry. The molecule exhibits excellent bench stability and compatibility with standard purification techniques.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.7823
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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