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5-Bromo-3-fluoro-2-nitropyridine

  • CAS No. 1532517-95-5

  • Cat. No. CS-0033199
  • Purity≥97%
  • MDL No.MFCD28129784

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-fluoro-2-nitropyridine|CS-0033199

Structure of 1532517-95-5

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General Information

  • CAS No. 1532517-95-5
  • Cat. No. CS-0033199
  • Purity ≥97%
  • MDL No. MFCD28129784
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrFN₂O₂
  • Molecular Weight 220.98
  • Synonym(s) None
  • SMILES FC1=C([N+]([O-])=O)N=CC(Br)=C1

Description

5-Bromo-3-fluoro-2-nitropyridine features a trifunctional pyridine core with bromo, fluoro, and nitro groups positioned for orthogonal reactivity. This electron-deficient heterocycle enables direct coupling in cross-coupling protocols and serves as a key intermediate in medicinal chemistry. The molecule exhibits robust stability under standard bench conditions and facilitates selective functionalization in complex synthesis workflows.

Application

5-Bromo-3-fluoro-2-nitropyridine serves as a versatile building block in medicinal chemistry, enabling regioselective functionalization via palladium-catalyzed cross-coupling reactions. The ortho-nitro and halogen substituents provide complementary reactivity for sequential transformations, while the fluorine atom enhances metabolic stability and modulates electronic properties. Bench-stable and compatible with standard purification protocols, it facilitates efficient synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.8914
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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