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CS-W001157 4
Total: USD 88.00

3,5-Dichloropyridine

  • CAS No. 2457-47-8

  • Cat. No. CS-W016343
  • Purity≥98%
  • MDL No.MFCD00006376

*For research and further manufacturing use only, not for direct human use.

3,5-Dichloropyridine|CS-W016343

Structure of 2457-47-8

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General Information

  • CAS No. 2457-47-8
  • Cat. No. CS-W016343
  • Purity ≥98%
  • MDL No. MFCD00006376
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂N
  • Molecular Weight 147.99
  • Synonym(s) None
  • SMILES C1=C(Cl)C=NC=C1Cl

Description

3,5-Dichloropyridine features a rigid heteroaromatic core with two chlorine substituents positioned at electron-deficient sites, enabling selective functionalization in cross-coupling and nucleophilic substitution reactions. This bench-stable compound serves as a key building block for pharmaceutical intermediates and agrochemicals, offering enhanced reactivity and predictable regiochemistry under standard conditions.

Application

3,5-Dichloropyridine serves as a versatile building block in synthetic organic chemistry, enabling selective functionalization at the C2 and C4 positions due to electronic deactivation of adjacent sites. Its high stability under standard reaction conditions facilitates nucleophilic substitution, cross-coupling, and heterocycle elaboration. The molecule's defined regiochemistry and excellent functional group tolerance make it ideal for constructing pharmaceutical intermediates and agrochemical scaffolds with predictable reactivity.

Synthesis

  • Route1

    References

    • Syngenta Limited Patent: US6639079 B1, 2003 ; Location in patent: Page/Page column 3-4 ;
  • Route2

    References

    • Syngenta Limited Patent: US6639079 B1, 2003 ; Location in patent: Page/Page column 2-3 ;
  • Route3

    References

    • Syngenta Limited Patent: US6639079 B1, 2003 ; Location in patent: Page/Page column 4 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3884
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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