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CS-W001157 4
Total: USD 88.00

5-Chloro-2-iodopyridine

  • CAS No. 244221-57-6

  • Cat. No. CS-W019023
  • Purity≥97%
  • MDL No.MFCD07368864

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-iodopyridine|CS-W019023

Structure of 244221-57-6

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General Information

  • CAS No. 244221-57-6
  • Cat. No. CS-W019023
  • Purity ≥97%
  • MDL No. MFCD07368864
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClIN
  • Molecular Weight 239.44
  • Synonym(s) 2-IODO-5-CHLOROPYRIDINE
  • SMILES ClC1=CN=C(C=C1)I

Description

5-Chloro-2-iodopyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling. The electron-deficient pyridine ring pairs with the iodide's high reactivity, enabling efficient Pd-catalyzed transformations. This bench-stable compound facilitates selective functionalization in synthetic sequences requiring orthogonal reactivity.

Application

5-Chloro-2-iodopyridine serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling the construction of biaryl and heteroaryl architectures. The orthogonal reactivity of the chloro and iodo groups facilitates sequential functionalization, while its bench-stable nature and compatibility with palladium- and nickel-catalyzed coupling protocols make it ideal for iterative synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3396
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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