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CS-W001157 4
Total: USD 88.00

2-Chloro-6-iodopyridine

  • CAS No. 258506-66-0

  • Cat. No. CS-0041633
  • Purity≥96%
  • MDL No.MFCD07784182
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-iodopyridine|CS-0041633

Structure of 258506-66-0

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Description

2-Chloro-6-iodopyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling. The chlorine and iodine substituents enable sequential functionalization, with the iodine group facilitating efficient Pd-catalyzed coupling and the chlorine offering orthogonal reactivity. This dual-halogenation pattern supports modular synthesis in medicinal chemistry and materials science.

Application

2-Chloro-6-iodopyridine serves as a versatile bifunctional building block in cross-coupling chemistry, enabling sequential functionalization at the 2- and 6-positions of the pyridine ring. The chlorine atom facilitates palladium-catalyzed coupling reactions under mild conditions, while the iodide group offers high reactivity in Suzuki, Stille, Negishi, and Sonogashira transformations. Its bench-stable nature and orthogonal reactivity profile make it ideal for constructing complex heterocyclic scaffolds in medicinal chemistry and materials science.

General Information

  • CAS No. 258506-66-0
  • Cat. No. CS-0041633
  • Purity ≥96%
  • MDL No. MFCD07784182
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClIN
  • Molecular Weight 239.44
  • Synonym(s) None
  • SMILES ClC1=NC(I)=CC=C1

Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3396
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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