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CS-W001157 4
Total: USD 88.00

4-Ethynyltetrahydro-2H-pyran

  • CAS No. 1202245-65-5

  • Cat. No. CS-0050867
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Ethynyltetrahydro-2H-pyran|CS-0050867

Structure of 1202245-65-5

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General Information

  • CAS No. 1202245-65-5
  • Cat. No. CS-0050867
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀O
  • Molecular Weight 110.15
  • Synonym(s) 4-Ethynyltetrahydropyran
  • SMILES C#CC1CCOCC1

Description

4-Ethynyltetrahydro-2H-pyran offers a reactive alkyne handle tethered to a stable tetrahydrolactone scaffold, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and polymer functionalization. The pyran ring provides conformational rigidity and enhanced solubility in polar organic solvents.

Application

4-Ethynyltetrahydro-2H-pyran serves as a versatile synthetic building block for the construction of heterocyclic scaffolds and bioactive molecules. Its terminal alkyne functionality enables reliable copper-catalyzed azide-alkyne cycloaddition (CuAAC) and Sonogashira coupling, while the tetrahydro-2H-pyran ring provides metabolic stability and favorable lipophilicity. The compound exhibits excellent bench stability, ease of handling, and compatibility with diverse functional groups, making it ideal for modular synthesis in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P210-P243-P273-P403

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   1.0462
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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