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CS-W001157 4
Total: USD 88.00

5,6-Difluoro-desamino lenalidomide

  • CAS No. 2438241-40-6

  • Cat. No. CS-0435100
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5,6-Difluoro-desamino lenalidomide|CS-0435100

Structure of 2438241-40-6

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Description

This piperidine-2,6-dione scaffold features a difluorinated isoindolinone moiety that enhances metabolic stability and modulates electronic properties. The fused ring system provides rigidity, enabling precise spatial orientation in target engagement. This structure serves as a key building block for bioactive molecules in medicinal chemistry, particularly in kinase inhibitor design and CNS-targeted drug discovery.

Application

3-(5,6-Difluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione serves as a versatile building block for the synthesis of bioactive heterocycles, leveraging the electrophilic isoindolinone core and flanking amide functionalities. Its difluorinated aromatic system enhances metabolic stability and modulates electronic properties, while the piperidinedione scaffold offers orthogonal reactivity for downstream functionalization. The compound exhibits bench stability and facilitates efficient conjugation in multistep syntheses, enabling rapid access to complex scaffolds relevant to medicinal chemistry campaigns.

General Information

  • CAS No. 2438241-40-6
  • Cat. No. CS-0435100
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀F₂N₂O₃
  • Molecular Weight 280.23
  • Synonym(s) None
  • SMILES O=C1NC(=O)C(N2C(=O)C3=CC(F)=C(F)C=C3C2)CC1

Computational Chemistry Data

  • TPSA   66.48
  • LogP   0.1406
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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