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CS-W001157 4
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(R)-(S)-Quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate Solifenacin Impurity

  • CAS No. 242478-37-1

  • Cat. No. CS-0167228
  • Purity≥98%
  • MDL No.MFCD18910847

*For research and further manufacturing use only, not for direct human use.

(R)-(S)-Quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate  Solifenacin Impurity|CS-0167228

Structure of 242478-37-1

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General Information

  • CAS No. 242478-37-1
  • Cat. No. CS-0167228
  • Purity ≥98%
  • MDL No. MFCD18910847
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₂₆N₂O₂
  • Molecular Weight 362.46
  • Synonym(s) None
  • SMILES O=C(O[C@H]1CN2CCC1CC2)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5

Synthesis

  • Route1
    • null|null
      1459721-13-1
    • In-stock
      1-Phenyl-1,2,3,4-tetrahydroisoquinoline|CS-B0307
      22990-19-8
    • ~91%
    • In-stock
      (R)-(S)-Quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate  Solifenacin Impurity|CS-0167228
      242478-37-1

    References

    • KYUNG DONG PHARM. CO., LTD.; LEE, Byoung Suk; SHIN, Sang Hoon; LEE, Ki Young Patent: WO2013/147458 A1, 2013 ; Location in patent: Paragraph 129-131 ;
  • Route2
    • Solifenacin impurity 2|CS-0915401
      1229227-22-8
    • null|null
      25333-42-0
    • ~74%
    • In-stock
      (R)-(S)-Quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate  Solifenacin Impurity|CS-0167228
      242478-37-1

    References

    • Wang, Sa; Onaran, M. Burak; Seto, Christopher T. Organic Letters, 2010 , vol. 12, # 12 p. 2690 - 2693
  • Route3
    • In-stock
      1-Phenyl-1,2,3,4-tetrahydroisoquinoline|CS-B0307
      22990-19-8
    • null|null
      25333-42-0
    • ~70%
    • In-stock
      (R)-(S)-Quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate  Solifenacin Impurity|CS-0167228
      242478-37-1

    References

    • CADILA HEALTHCARE LIMITED; KOTHARI, Himanshu M.; DAVE, Mayank Ghanshyambhai; PANDEY, Bipin Patent: WO2011/48607 A1, 2011 ; Location in patent: Page/Page column 16 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H361
Precautionary Statements : P280-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.78
  • LogP   3.8649
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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