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CS-W001157 4
Total: USD 88.00

3-(4-(tert-Butoxycarbonyl)piperazin-1-yl)propanoic acid

  • CAS No. 242459-97-8

  • Cat. No. CS-0128680
  • Purity≥97%
  • MDL No.MFCD03410257

*For research and further manufacturing use only, not for direct human use.

3-(4-(tert-Butoxycarbonyl)piperazin-1-yl)propanoic acid|CS-0128680

Structure of 242459-97-8

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General Information

  • CAS No. 242459-97-8
  • Cat. No. CS-0128680
  • Purity ≥97%
  • MDL No. MFCD03410257
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₂N₂O₄
  • Molecular Weight 258.31
  • Synonym(s) 3-(1-TERT-BUTOXYCARBONYLPIPERAZIN-4-YL)PROPIONIC ACID
  • SMILES OC(CCN1CCN(C(OC(C)(C)C)=O)CC1)=O

Description

This piperazine-based carboxylic acid features a tert-butyl carbamate-protected amine, enabling selective derivatization in peptide and macrocycle synthesis. The aliphatic spacer provides flexibility and solubility, while the protected amine resists premature reactivity under standard conditions.

Application

3-(4-(tert-Butoxycarbonyl)piperazin-1-yl)propanoic acid serves as a versatile building block for peptide and small-molecule synthesis, enabling the introduction of piperazine-based pharmacophores with controlled solubility and stability. The tert-butyl carbamate group provides orthogonal protection for amine functionalities, allowing selective deprotection under mild acidic conditions. This derivative exhibits excellent bench stability, facilitates efficient purification via standard chromatographic methods, and functions effectively in diverse coupling reactions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   70.08
  • LogP   1.0138
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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